This property soon become too small and in 1875 the hospital, now known as the Home for Incurables, moved to the building on Upper Parliament Street where it remained for the rest of its existence. The home was now run by a General Committee for 'respectable' women with incurable, chronic illnesses. Admissions of cancer sufferers were limited as were geriatric cases. Although many patients spent the remainder of their lives there, others improved and were discharged, so there was some degree of patient turnover.

After 1885 the home was known as the Liverpool Home for Incurables, a name it kept until its absorption into the National Health Service. From 1948 under the South Liverpool Hospital Management Committee it was renamed the Home for Invalid Women. In 1969 home's name was again changed, to Princes Park Hospital. Although it aimed to care for younger chronically sick women, increasingly its intake was of geriatric patients. After 1975 the hospital admitted male as well as female patients. The hospital closed in 1986.